This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.
SUMMARY
- Johnson & Johnson cannot recommend any practices, procedures, or dosage administration techniques that deviate from the approved product labeling.
- ERLEADA 240 mg is not commercially available as a solution or suspension.
- For patients with a feeding tube, the ERLEADA 240 mg tablet can be administered through a feeding tube 8 French or greater.1
- Results from in vitro studies to evaluate compatibility of 1 dispersed 240 mg tablet administered via nasogastric (NG) tubes of ≥8 French diameter made of polyurethane, silicone, or polyvinyl chloride have been published.2
ALTERNATE METHOD OF ADMINISTRATION
Administer 240 mg Tablet Through a Feeding Tube
ERLEADA 240 mg tablet can be administered through a feeding tube 8 French or greater as follows1:
- Place one 240 mg tablet in the barrel of the syringe (use at least a 20 mL syringe) and draw up 10 mL of non-carbonated water into the syringe.
- Wait 10 minutes and then shake vigorously to disperse contents completely.
- Administer immediately through the feeding tube.
- Refill the syringe with non-carbonated water and administer. Repeat until no tablet residue is left in the syringe or feeding tube.
Literature Search
A literature search of MEDLINE®, Embase®, BIOSIS Previews®, and Derwent Drug File (and/or other resources, including internal/external databases) was conducted on 10 July 2024.
1 | Data on File. Apalutamide. Company Core Data Sheet. Janssen Research & Development, LLC. EDMS-ERI-146013831; 2024. |
2 | Yu A, Uffel MV, Jiao JJ, et al. Bioequivalence of 240 mg apalutamide tablets and preparation in aqueous food vehicles for alternative administration. Clin Pharmacol Drug Dev. 2024;13(4):432-439. |