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This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.

INVEGA HAFYERA® (paliperidone palmitate 6-month)

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Dosing of INVEGA HAFYERA - Maximum Dose

Last Updated: 10/01/2024

SUMMARY

The maximum dose of INVEGA HAFYERA injection is 1,560 mg every 6 months. Doses higher than INVEGA HAFYERA 1,560 mg have not been evaluated.¹
INVEGA HAFYERA has not been systematically studied in patients with renal impairment.¹
For patients with mild renal impairment (creatinine clearance ≥50 mL/min to <80 mL/min [Cockcroft-Gault Formula]), adjust dosage and stabilize patient using INVEGA SUSTENNA or INVEGA TRINZA before transitioning to INVEGA HAFYERA.²
- Please see the respective Prescribing Information for the recommended dosage of INVEGA SUSTENNA and INVEGA TRINZA in patients with mild renal impairment.³^,⁴
Use of INVEGA HAFYERA is not recommended for use in patients with moderate or severe renal impairment (creatinine clearance <50 mL/min).²

Literature Search

A literature search of MEDLINE^®, Embase^®, BIOSIS Previews^®, and Derwent Drug File (and/or other resources, including internal/external databases) pertaining to this topic was conducted on 13 September 2024.

References

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1	Data on File. Paliperidone palmitate 6-month injection, Version 002. Janssen Research & Development, LLC; Paliperidone Palmitate CCDS; 2022.
2	INVEGA HAFYERA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+HAFYERA-pi.pdf.
3	INVEGA SUSTENNA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf.
4	INVEGA TRINZA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf.