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Comparison of INVEGA SUSTENNA or INVEGA TRINZA to ABILIFY ASIMTUFII® (aripiprazole)

Last Updated: 04/26/2024

SUMMARY

  • Abilify Asimtufii (aripiprazole) is an intramuscular gluteal injection administered by a healthcare professional once every 2-months for treatment of adults with schizophrenia and as maintenance monotherapy for adults with bipolar I disorder.1
  • There are currently no head-to-head studies examining the efficacy and safety of INVEGA SUSTENNA or INVEGA TRINZA compared to Abilify Asimtufii.2,3

BACKGROUND

Abilify Asimtufii (960 mg and 720 mg) is administered once every 2-months in the gluteal muscle by a healthcare professional and is indicated for the treatment of schizophrenia and as maintenance monotherapy for bipolar I disorder in adults.1

For questions on this product, please refer to the manufacturer.

INVEGA SUSTENNA (39 mg, 78 mg, 117 mg, 156 mg, and 234 mg) is a 1-month intramuscular deltoid or gluteal injection administered by a healthcare professional. INVEGA SUSTENNA is indicated in adults for the treatment of schizophrenia and schizoaffective disorder as monotherapy and as an adjunct to mood stabilizers or antidepressants.2

INVEGA TRINZA (273 mg, 410 mg, 546 mg, or 819 mg) is a 3-month intramuscular deltoid or gluteal injection administered by a healthcare professional. INVEGA TRINZA is indicated for the treatment of schizophrenia in adults after they have been adequately treated with INVEGA SUSTENNA for at least four months.3

Literature Search

A literature search of MEDLINE®, EMBASE®, BIOSIS Previews®, DERWENT® (and/or other resources, including internal/external databases) pertaining to this topic was conducted on 12 April 2024.

References

1 ABILIFY ASIMTUFII (aripiprazole) extended-release injectable suspension [Prescribing Information]. Rockville, MD: Otsuka America Pharmaceutical, Inc; https://www.otsuka-us.com/sites/g/files/qhldwo7066/files/media/static/Abilify-Asimtufii-PI.pdf.  
2 INVEGA SUSTENNA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf.  
3 INVEGA TRINZA (paliperidone palmitate) extended-release injectable suspension [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc; https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf.