SUMMARY  

How do INVEGA SUSTENNA, INVEGA TRINZA, or INVEGA HAFYERA work?

INVEGA SUSTENNA, INVEGA TRINZA, and INVEGA HAFYERA are given as injections by your healthcare provider into the muscle (intramuscularly).^1-3

They each have the same ingredient, paliperidone palmitate, which your body will metabolize or break down over time into the active medication, paliperidone. However, each product is designed, so that the active medication is gradually released into the body over different periods of time.  

• The active medication in INVEGA SUSTENNA is gradually released into the body over 1 month (after receiving 2 starting doses administered 1 week apart).¹
• The active medication in INVEGA TRINZA is gradually released into the body over 3 months (after being adequately treated with INVEGA SUSTENNA for at least 4 months).²
• The active medication in INVEGA HAFYERA is gradually released into the body over 6 months (after being adequately treated with INVEGA SUSTENNA for at least 4 months or INVEGA TRINZA for one 3-month cycle).³

How paliperidone works in the body (sometimes called the mechanism of action) is unclear. However, these medicines are believed to act by blocking certain types of receptors within the brain for the neurotransmitters, dopamine and serotonin.^1-3

Additonal information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for INVEGA SUSTENNA, INVEGA TRINZA, and INVEGA HAFYERA.^1-3