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Here is a passage from the LAZCLUZE PATIENT INFORMATION which may be helpful to address your question:

Can LAZCLUZE cause skin problems?

• LAZCLUZE may cause serious side effects, including skin problems.¹
  • LAZCLUZE may cause severe rash including redness, raised acne-like bumps, itching, and dry skin. You may use alcohol-free (such as isopropanol-free, ethanol-free) moisturizing cream to reduce the risk of skin problems.
  • Limit sun exposure during and for 2 months after treatment with LAZCLUZE. Wear protective clothing and use sunscreen.
  • Tell your healthcare provider right away if you get any skin reactions. Your healthcare provider may recommend that you start a medicine to prevent skin problems, may treat you with a medicine(s), or send you to see a skin specialist (dermatologist) if you get skin reactions during treatment with LAZCLUZE.

Some of the most common skin side effects of LAZCLUZE when given in combination with amivantamab include rash, infected skin around the nail, and itchy skin.¹

Your healthcare provider may temporarily stop, decrease your dose or completely stop your treatment with LAZCLUZE if you have serious side effects.¹

These are not all of the possible side effects of LAZCLUZE.¹

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1800FDA1088.¹

PRODUCT LABELING

• LAZCLUZE (lazertinib) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/LAZCLUZE-pi.pdf.
• RYBREVANT (amivantamab-vmjw) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT-pi.pdf.

ADDITIONAL INFORMATION

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medicasl treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for LAZCLUZE.¹