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Here is a passage from the LAZCLUZE PATIENT INFORMATION which may be helpful to address your question:

What are the possible side effects of LAZCLUZE?

LAZCLUZE may cause serious side effects, including:

• blood clot problems. Blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) are serious, but common, and may lead to death. Your healthcare provider will start you on medicine to prevent blood clots for the first four months of treatment. Tell your healthcare provider right away if you have any signs and symptoms of blood clots, including swelling, pain or tenderness in the leg, sudden unexplained chest pain, or shortness of breath.¹
• lung problems. LAZCLUZE may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you get any new or worsening lung symptoms, including shortness of breath, cough, or fever.¹
• skin problems. LAZCLUZE may cause severe rash including redness, raised acne-like bumps, itching, and dry skin. You may use alcohol-free (such as isopropanol-free, ethanol-free) moisturizing cream to reduce the risk of skin problems. Limit sun exposure during and for 2 months after treatment with LAZCLUZE. Wear protective clothing and use sunscreen. Tell your healthcare provider right away if you get any skin reactions. Your healthcare provider may recommend that you start a medicine to prevent skin problems, may treat you with a medicine(s), or send you to see a skin specialist (dermatologist) if you get skin reactions during treatment with LAZCLUZE.¹
• eye problems. LAZCLUZE may cause eye problems such as inflamed cornea (front part of your eye). Tell your healthcare provider right away if you get symptoms such as eye redness, eye pain, new or worsening problems with vision, and sensitivity to light.¹
  • Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get eye problems during treatment with LAZCLUZE. You should not use contact lenses until your eye symptoms are checked by a healthcare provider.

The most common side effects of LAZCLUZE in combination with amivantamab include¹:

• rash
• infected skin around the nail
• infusion-related reaction (amivantamab)
• muscle and joint pain
• sores in the mouth
• swelling of hands, ankles, feet, face, or all of your body
• unusual feeling in the skin (such as tingling or crawling)
• feeling very tired
• diarrhea
• constipation
• COVID-19
• bleeding
• decreased appetite
• itchy skin
• nausea
• changes in certain blood tests

LAZCLUZE may cause fertility problems in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.¹

Your healthcare provider may temporarily stop, decrease your dose or completely stop your treatment with LAZCLUZE if you have serious side effects.¹

These are not all of the possible side effects of LAZCLUZE.¹

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1800FDA1088.¹

PRODUCT LABELING

• LAZCLUZE (lazertinib) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/LAZCLUZE-pi.pdf.
• RYBREVANT (amivantamab-vmjw) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT-pi.pdf.

ADDITIONAL INFORMATION

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for LAZCLUZE.¹