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Here is a passage from the RYBREVANT PATIENT INFORMATION which may be helpful to address your question:

What are the possible side effects of RYBREVANT?

RYBREVANT may cause serious side effects, including:

• infusion-related reactions. Infusion-related reactions are common but can be severe or serious. Tell your healthcare provider right away if you get any of the following symptoms during your infusion of RYBREVANT¹:
  • shortness of breath
  • fever
  • chills
  • nausea
  • flushing
  • chest discomfort
  • lightheadedness
  • vomiting
• lung problems. RYBREVANT may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you get any new or worsening lung symptoms, including shortness of breath, cough, or fever.¹
• blood clot problems. Blood clots are a serious, but common side effect of RYBREVANT, when given together with another drug called lazertinib, may cause blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) that may lead to death.¹
  • Your healthcare provider will start you on medicine to prevent blood clots for the first 4 months of treatment.
  • Tell your healthcare provider right away if you have any signs and symptoms of blood clots, including swelling, pain or tenderness in the leg, sudden unexplained chest pain, or shortness of breath.
• skin problems. RYBREVANT can cause severe rash; including blisters, peeling, skin pain and sores, redness, raised acne-like bumps, itching, and dry skin. You may use alcohol-free (such as isopropanol-free, ethanol-free) moisturizing cream to reduce the risk of skin problems.¹
  • Tell your healthcare provider right away if you get any skin reactions. Your healthcare provider may treat you with a medicine(s) or send you to see a skin specialist (dermatologist) if you get skin reactions during treatment with RYBREVANT.
  • RYBREVANT can cause skin reactions. You should limit your time in the sun during and for 2 months after your treatment with RYBREVANT. Wear protective clothing and use sunscreen during treatment with RYBREVANT.
• eye problems. RYBREVANT may cause eye problems. Tell your healthcare provider right away if you get symptoms of eye problems which may include¹:
  • eye pain
  • inflammation of eye lids
  • dry eyes
  • eye redness
  • blurred vision
  • changes in vision
  • itchy eyes
  • excessive tearing
  • sensitivity to light

Your healthcare provider may send you to see an eye specialist (ophthalmologist) if you get new or worsening eye problems during treatment with RYBREVANT. You should not use contact lenses until your eye symptoms are checked by a healthcare provider.¹

The most common side effects of RYBREVANT when given in combination with lazertinib include¹:

• rash
• infected skin around the nail
• diarrhea
• constipation
• COVID-19
• muscle and joint pain
• sores in the mouth
• swelling of the hands, ankles, feet, face, or all of your body
• unusual feeling in the skin (such as tingling or a crawling feeling)
• feeling very tired
• dry skin
• bleeding
• decreased appetite
• itchy skin
• nausea
• changes in certain blood tests

The most common side effects of RYBREVANT when given in combination with carboplatin and pemetrexed include¹:

• rash
• infected skin around the nail
• feeling very tired
• nausea
• sores in the mouth
• constipation
• swelling of hands, ankles, feet, face, or all of your body
• decreased appetite
• muscle and joint pain
• vomiting
• COVID-19
• changes in certain blood tests

The most common side effects of RYBREVANT when given alone¹:

• rash
• infected skin around the nail
• muscle and joint pain
• shortness of breath
• nausea
• feeling very tired
• swelling of hands, ankles, feet, face, or all of your body
• sores in the mouth
• cough
• constipation
• vomiting
• changes in certain blood tests

Your healthcare provider may temporarily stop, decrease your dose, or completely stop your treatment with RYBREVANT if you have serious side effects.¹

These are not all of the possible side effects of RYBREVANT.¹

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.¹

PRODUCT LABELING

• RYBREVANT (amivantamab-vmjw) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/RYBREVANT-pi.pdf.
• LAZCLUZE (lazertinib) [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc.; http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/LAZCLUZE-pi.pdf.

ADDITIONAL INFORMATION

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT INFORMATION for RYBREVANT.¹