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This information is intended for US healthcare professionals to access current scientific information about J&J Innovative Medicine products. It is prepared by Medical Information and is not intended for promotional purposes, nor to provide medical advice.

TREMFYA® (guselkumab)

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TREMFYA - Retreatment of Active Psoriatic Arthritis after a Drug Free Interval

Last Updated: 01/04/2025

SUMMARY

The company cannot recommend any practices, procedures, or usage that deviate from the approved labeling.
Please refer to the local labeling for relevant information on dosage and administration of TREMFYA.
The 2 phase 3 (DISCOVER-1 and DISCOVER-2) and the phase 3b (COSMOS) clinical trials that evaluated the efficacy and safety of TREMFYA in the treatment of active psoriatic arthritis (PsA) did not evaluate retreatment after a drug free interval.¹^-³

Literature Search

A literature search of MEDLINE^®, EMBASE^®, BIOSIS Previews^®, and Derwent^® (and/or other resources, including internal/external databases) conducted on 11 June 2024 did not identify any relevant literature pertaining to this topic.

References

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1	Deodhar A, Helliwell PS, Boehncke WH, et al. Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial [published correction appears in Lancet. 2020 Apr 4;395(10230):1114. Lancet. 2020;395(10230):1115-1125.
2	Mease PJ, Rahman P, Gottlieb AB, et al. Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial [published correction appears in Lancet. 2020 Apr 4;395(10230):1114. Lancet. 2020;395(10230):1126-1136.
3	Coates LC, Gossec L, Theander E, et al. Efficacy and safety of guselkumab in patients with active psoriatic arthritis who demonstrated inadequate response to tumor necrosis factor inhibition: results of a phase 3b, randomized, controlled study. Oral Presentation presented at: European League Against Rheumatism (EULAR); June 2-5, 2021; Virtual Congress.