SUMMARY

• There are no sponsored studies investigating the administration or the clinical safety of crushed, broken, or reformulated UPTRAVI tablets.

CLINICAL DATA

During photostability studies, it was demonstrated that the selexipag core tablets are sensitive to light. In order to protect the core tablet from light-induced degradation, an appropriate film coating was developed and applied.¹ Tablets should not be split, crushed or chewed, and are to be swallowed with some water.²

Literature Search

A literature search of MEDLINE^®, EMBASE^®, BIOSIS Previews^®, DERWENT^® (and/or other resources, including internal/external databases) was conducted on 23 April 2024.