importaNT INFORMATION ABOUT XARELTO

• Early discontinuation of XARELTO may increase the risk of formation of blood clots. People with atrial fibrillation (a type of irregular heartbeat) that is not caused by a heart valve problem (nonvalvular) are at an increased risk of forming a blood clot in the heart, which can travel to the brain, causing a stroke, or to other parts of the body. XARELTO lowers your chance of having a stroke by helping to prevent clots from forming.¹
  • Do not stop taking XARELTO without talking to the doctor who prescribes it for you. If you have to stop taking XARELTO, your doctor may prescribe another blood thinner to prevent a blood clot from forming. 
• XARELTO can cause bleeding which can be serious and may lead to death. During treatment with XARELTO, you are likely to bruise more easily, and it may take longer for the bleeding to stop. You may have a higher risk of bleeding if you take XARELTO and have certain other medical problems or take other medicines that increase your risk of bleeding. Please see the MEDICATION GUIDE for a list of other medications that increase your risk of bleeding and signs or symptoms of bleeding.¹
  • Call your doctor or get medical help right away if you or your child develop any signs or symptoms of bleeding.
• People who take a blood thinner medicine (anticoagulant) like XARELTO, and have medicine injected into their spinal and epidural area, or have a spinal puncture have a risk of forming a blood clot that can cause long-term or permanent loss of the ability to move (paralysis).Please see MEDICATION GUIDE for a list of risk factors and symptoms of spinal or epidural blood clots.¹

summary

Here is a passage from the XARELTO MEDICATION GUIDE which may be helpful to address your question:

What Should I Mention to my Healthcare Provider Before Starting XARELTO?

Before taking XARELTO, tell your doctor about all your medical conditions, including if you or your child:

• have or ever had bleeding problems¹
• have liver or kidney problems¹
• have antiphospholipid syndrome (APS)¹
• are pregnant or plan to become pregnant. It is not known if XARELTO will harm your unborn baby.¹
  • Tell your doctor right away if you become pregnant during treatment with XARELTO. Taking XARELTO while you are pregnant may increase the risk of bleeding in you or in your unborn baby.
  • If you are able to become pregnant, talk with your doctor about pregnancy planning during treatment with XARELTO. Talk with your doctor about your risk for severe uterine bleeding if you are treated with blood thinner medicines, including XARELTO.
  • If you take XARELTO during pregnancy, tell your doctor right away if you develop any signs or symptoms of bleeding or blood loss, including:
    • Unexpected bleeding or bleeding that last for a long time, such as:
      • nosebleeds that happen often
      • unusual bleeding from gums
      • menstrual bleeding that is heavier than usual, or vaginal bleeding
    • bleeding that is severe or you cannot control
    • red, pink, or brown urine
    • bright red or black stools (looks like tar)
    • cough up blood or blood clots
    • vomit blood or your vomit looks like “coffee grounds”
    • headaches, feeling dizzy or weak
    • pain, swelling, or new drainage at wound site
• are breastfeeding or plan to breastfeed. XARELTO can pass into your breast milk. Talk to your doctor about the best way to feed your baby during treatment with XARELTO.¹

Tell all of your doctors and dentists if you or your child are taking XARELTO. They should talk to the doctor who prescribed XARELTO to you before you have any surgery, medical or dental procedure.¹

Tell your doctor about all the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.¹

Some of your other medicines may affect the way XARELTO works, causing side effects. Certain medicines you take may increase the risk of bleeding, including¹:

• aspirin or aspirin containing products
• long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
• warfarin sodium (Coumadin^®, Jantoven^®)
• any medicine that contains heparin
• clopidogrel (Plavix^®)
• selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)
• other medicines to prevent or treat blood clots

Especially tell your doctor if you or your child take¹:

• ketoconazole
• ritonavir
• erythromycin
• carbamazepine
• phenytoin
• rifampin
• St. John’s wort

additional information

This information is provided ONLY in response to your request and is not intended as medical advice, to promote the use of our product, or suggest using it in any manner other than as described in the PRESCRIBING INFORMATION. All decisions regarding your medical treatment should be made with your healthcare professional(s). Please contact your healthcare professional(s) to discuss the information in this response.

Please refer to the attached full PRESCRIBING INFORMATION and the PATIENT MEDICATION GUIDE for XARELTO.¹