When switching patients currently at steady-state on a long-acting injectable antipsychotic, initiate INVEGA SUSTENNA therapy in place of the next scheduled injection. INVEGA SUSTENNA should then be continued at monthly intervals. The one-week initiation dosing regimen (234 mg on day 1 and 156 mg one week later) is not required.¹

Switching From RISPERDAL CONSTA to INVEGA SUSTENNA

Doses of RISPERDAL CONSTA and INVEGA SUSTENNA Needed to Attain Similar Levels of Active Moiety Exposure at Steady State²

Formulation	RISPERDAL CONSTA	INVEGA SUSTENNA
Dosing Frequency	Every 2 weeks	Once every 4 weeks
Dose	12.5 mg	39 mg
	25 mg	78 mg
	37.5 mg	117 mg
	50 mg	156 mg

Plasma concentrations of the active moiety are maintained close to steady-state concentrations after the switch from RISPERDAL CONSTA to INVEGA SUSTENNA. No oral supplementation is required during the switch in treatment.²

Clinical Rationale

Results from PK modeling simulations suggest that patients previously stabilized on RISPERDAL CONSTA can attain similar levels of active moiety steady-state exposure during maintenance treatment with specific monthly doses of INVEGA SUSTENNA.²

PK, pharmacokinetic.