• The initiation regimen for INVEGA SUSTENNA was designed to rapidly attain steady-state paliperidone concentrations when initiating therapy without the use of oral antipsychotic supplementation.
• To avoid a missed dose, patients may be given the second initiation dose 4 days before or after the one-week time point.
• Five weeks following the first initiation dose and monthly thereafter (± 1 week), maintenance doses can be administered in either the deltoid or gluteal muscle for sustained plasma levels up to one month.

^aTo help attain therapeutic concentrations rapidly

BMI, body mass index; ER, extended release; IM, intramuscular; PK, pharmacokinetic.